{"id":373,"date":"2017-05-13T20:03:00","date_gmt":"2017-05-13T20:03:00","guid":{"rendered":"https:\/\/solfed.fr\/?p=373"},"modified":"2025-09-21T20:31:42","modified_gmt":"2025-09-21T20:31:42","slug":"pcsk9","status":"publish","type":"post","link":"https:\/\/solfed.fr\/?p=373","title":{"rendered":"PCSK9"},"content":{"rendered":"\n<p>Lors des <strong>6\u00e8mes Journ\u00e9es M\u00e9dicales SOLFED (2017)<\/strong>, la Dre <strong>Mathilde Varret<\/strong> a pr\u00e9sent\u00e9 l\u2019histoire passionnante du <strong>PCSK9<\/strong>, une prot\u00e9ine cl\u00e9 dans la r\u00e9gulation du cholest\u00e9rol et de la sant\u00e9 cardiovasculaire.<\/p>\n\n\n\n<p>La pr\u00e9sentation a abord\u00e9 :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>La <strong>d\u00e9couverte du PCSK9<\/strong> et son r\u00f4le dans l\u2019hypercholest\u00e9rol\u00e9mie familiale.<\/li>\n\n\n\n<li>Les effets des <strong>mutations du PCSK9<\/strong> : certaines provoquent une \u00e9l\u00e9vation du LDL-cholest\u00e9rol (gain de fonction), tandis que d\u2019autres entra\u00eenent naturellement de faibles taux de LDL et une r\u00e9duction du risque cardiovasculaire (perte de fonction).<\/li>\n\n\n\n<li>Les <strong>m\u00e9canismes d\u2019action du PCSK9<\/strong>, notamment sur la d\u00e9gradation des r\u00e9cepteurs LDL, le m\u00e9tabolisme des lipoprot\u00e9ines, ainsi que son implication possible dans le diab\u00e8te, la septic\u00e9mie et des r\u00e9gulations d\u00e9pendantes du sexe.<\/li>\n\n\n\n<li>L\u2019\u00e9mergence des <strong>th\u00e9rapies anti-PCSK9<\/strong> (\u00e9volocumab, alirocumab), qui ont r\u00e9volutionn\u00e9 la prise en charge de l\u2019hypercholest\u00e9rol\u00e9mie en r\u00e9duisant fortement le LDL et en diminuant le risque d\u2019\u00e9v\u00e9nements cardiovasculaires majeurs dans les grands essais cliniques.<\/li>\n\n\n\n<li>L\u2019impact mondial de l\u2019<strong>hypercholest\u00e9rol\u00e9mie familiale (HF)<\/strong>, encore trop souvent sous-diagnostiqu\u00e9e et sous-trait\u00e9e malgr\u00e9 son r\u00f4le majeur dans les maladies cardiovasculaires pr\u00e9coces.<\/li>\n<\/ul>\n\n\n\n<p>Cette pr\u00e9sentation met en lumi\u00e8re l\u2019importance du PCSK9 en tant que <strong>d\u00e9couverte scientifique et cible th\u00e9rapeutique<\/strong>, ouvrant une nouvelle \u00e8re dans la m\u00e9decine cardiovasculaire.<\/p>\n\n\n\n<p>\ud83d\udc49 T\u00e9l\u00e9chargez le PDF complet pour explorer en d\u00e9tail les donn\u00e9es et r\u00e9sultats pr\u00e9sent\u00e9s.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lors des 6\u00e8mes Journ\u00e9es M\u00e9dicales SOLFED (2017), la Dre Mathilde Varret a pr\u00e9sent\u00e9 l\u2019histoire passionnante du PCSK9, une prot\u00e9ine cl\u00e9 dans la r\u00e9gulation du cholest\u00e9rol et de la sant\u00e9 cardiovasculaire. La pr\u00e9sentation a abord\u00e9 : Cette pr\u00e9sentation met en lumi\u00e8re l\u2019importance du PCSK9 en tant que d\u00e9couverte scientifique et cible th\u00e9rapeutique, ouvrant une nouvelle \u00e8re [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":36,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[13],"tags":[],"class_list":["post-373","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-13"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PCSK9 - Solfed<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/solfed-bc8f75.ingress-daribow.ewp.live\/?p=373\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PCSK9 - Solfed\" \/>\n<meta property=\"og:description\" content=\"Lors des 6\u00e8mes Journ\u00e9es M\u00e9dicales SOLFED (2017), la Dre Mathilde Varret a pr\u00e9sent\u00e9 l\u2019histoire passionnante du PCSK9, une prot\u00e9ine cl\u00e9 dans la r\u00e9gulation du cholest\u00e9rol et de la sant\u00e9 cardiovasculaire. 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